History of ingenious targeting laboratory
ingenious targeting laboratory's story began in the early 1990s. The founders worked as researchers in the same lab at Rockefeller University. During their time at Rockefeller, they developed custom atherosclerotic knockout mouse models for studying heart disease. In 1998, they founded ingenious targeting laboratory and still continue to work directly in the lab, oversee mouse model production, and also handle the operation and business side of things.
As ingenious targeting laboratory, we first settled in at the Long Island High Technology Incubator (LIHTI) at Stony Brook University, discussing and sharing ideas with other researchers and companies in that space. A little over 10 years later, we expanded and moved to a larger facility on Long Island with 20,000 square feet. We still work closely with Stony Brook's Division of Laboratory Animal Resources (DLAR) to house many of our mice.
From our small beginnings as one of the very first mouse gene targeting companies in the world, we've grown and streamlined our model generation process. Today ingenious uses both traditional and cutting edge technologies to design custom mouse lines for our clients globally.
Our Location
Holbrook, New York
Our corporate headquarters and laboratories are located in Holbrook, New York, USA. We are fortunate to be surrounded by, and enjoy relationships with, world class research institutions such as Stony Brook University, Cold Spring Harbor and Brookhaven National Laboratory.
In addition, being located near New York City places us at a global hub of travel, providing us with a gateway to our clients across the USA and the world. Our convenient location also gives us the opportunity to bring top talent to the ingenious team.
761-80 Coates Avenue
Holbrook, NY 11741
All Work Performed in the USA 🇺🇸
Research Partnerships
Stony Brook University
Division of Laboratory Animal Resources (DLAR)
Cold Spring Harbor Laboratory
World renowned research institution
Brookhaven National Laboratory
Leading scientific research center
Dedicated scientists are with you from start to finish
Drs. Jennifer Parla, Milen Kirilov, and Arielle Bryan are part of our team of scientific experts who work directly in the lab and oversee every aspect of your project.
Our Guarantee
As part of our commitment to you, we guarantee delivery of your germline confirmed F1 heterozygous mice. We achieve our guarantee by providing the following:
Best Quality Constructs
Best quality targeting vector constructs, ranging in sizes from plasmid to BAC.
Proprietary ES Cell Lines
Proprietary mouse ES cell lines that consistently and reliably transmit to germline.
FLP ES Cell Technology
Our own FLP ES cell technology for streamlined deletion of antibiotic selection cassette without extra steps.
With our guarantee, you can be confident in knowing that you will receive the mice you need at the cost you agreed to.
Why researchers choose ingenious targeting laboratory
Certainty
The model you design is the model we deliver.
Guaranteed Delivery
Assurance of your mouse model, not just your money back.
Value
Our proprietary technologies save time and money.
Trusted Precision
Exactly what you need, our experts make it happen.
Fast Timelines
Germline in less time than ever before.
Assured Quality
The quality you need, the value you seek.
"iTL generated our angiotensin II type 1a receptor conditional mouse. We found this company very responsive. The project started with discussions on possible construct designs. Following approval, a project manager sent monthly reports alerting us to project milestones. Our experience with iTL was so positive that we have generated more conditional mice with them."
— Debra Rateri, BS, University of Kentucky
Start your project today
Our scientific consultants are ready to discuss your research requirements and recommend the optimal approach for your program. Initial consultation is provided at no charge.
What makes ingenious targeting laboratory different
ingenious targeting laboratory (iTL) is a U.S. based custom mouse model company that has delivered 2,500+ genetically engineered mouse models since 1998. Researchers select iTL when allele complexity, scientific oversight, and long term inheritance stability matter to the outcome of their study.
100% germline transmission guarantee
Every custom mouse model project is backed by a 100% germline transmission guarantee. Researchers do not pay for a model that fails to transmit through the germline. The guarantee covers both ES cell and CRISPR generated models.
U.S. based scientific oversight at every QC stage
Allele design, vector construction, ES cell targeting or CRISPR editing, microinjection, founder screening, germline confirmation, and cohort breeding are all performed and quality controlled in the United States by an in house PhD scientific team.
Specialists in complex multi allele and humanized models
iTL is selected for projects other providers consider too complex: stacked alleles, conditional knockouts with multiple loxP cassettes, large humanizations, BAC transgenics, and safe harbor integrations at Rosa26 and H11.
27 years, 2,500+ projects, 800+ peer reviewed publications
Continuous gene targeting experience since 1998 means stable protocols, validated reagents, and accumulated knowledge across every major therapeutic area. iTL generated models have appeared in Nature, Science, Cell, and the Journal of Clinical Investigation.
Defined C57BL/6 backgrounds for cohort reproducibility
C57BL/6J and C57BL/6N are the primary working strains for cohort reproducibility, immunological consistency, and multi site study design. BALB/c, 129, and hybrid backgrounds are available on request.