Genetically Humanized Catalog Mouse Models

Study-ready, dependable, and competitively priced.

Ingenious targeting laboratory offers over 500 genetically humanized, study-ready mouse models to streamline human disease research and drug development. Our catalog includes models for immune checkpoints, tumor targets, cytokines, metabolic targets, viral infection receptors and more - all backed by 30 years of expertise and comprehensive support. Our competitively priced, dependable models allow for accelerated delivery compared to custom models, enabling advanced, relevant, and robust research outcomes. Download our catalog to explore our extensive offerings for your next breakthrough in drug discovery and disease modeling.

Start your purchase!

“I worked with ITL on the generation of a conditional knockout mouse strain for a complex gene. I have been very impressed by their flexibility and their efficiency in completing each steps with no delays. I’m glad to share this experience and highly recommend ITL’s services.”– Frédéric Marmigère, PhD INSERM

Explore Over 500+ Genetically Humanized Mouse Models

An image of a C57BL/6 mouse.

Tumor Targets

Humanized tumor target mice are immunocompetent mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigens, etc. These models can be used to evaluate the risk of on-target, off-tumor toxicities for targeted cancer drugs.

Models available include:
hCD19 | hPD-L1 | hCD47hVEGFR2 | hHER3 | hNECTIN4hTFR1 | hSORT1 | hCLDN18.2-TghPD - L1/hCD28
And more...

download our catalog
An image of a C57BL/6 mouse.

Immune Checkpoints

These mice express humanized immune checkpoint genes. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice. We offer:

SINGLE IMMUNE CHECKPOINTDouble Immune checkpoint miceTriple Immune checkpoint mice

Models available include:
hCTLA-4 | hFCRN | hLAG3hPD-1 | hVISTA | hSIGLEC15h4-1BB | hVSIG4 | hCD3EDGhPD-1/hCD28 | hPD-1/hPD-L1
And more...

download our catalog
An image of a C57BL/6 mouse.

Complement

These mouse models express humanized complement genes. These models are suitable to assess the efficacy of drugs targeting complement in fully immunocompetent mice.

Models available include:
hC5  | hC1R | hMASP2 hC1S | hCFB | hC3 | hC5AR1/C5AR2
And more...

download our catalog
An image of a C57BL/6 mouse.

Cytokines

Cytokines play key roles in host immune responses to infection, inflammation, trauma, sepsis, cancer, and reproduction. These mouse models express humanized cytokine genes. These models are suitable to assess the efficacy of drugs targeting cytokines in fully immunocompetent mice.

Models available include:
hCSF1 | hCSF2 | hMIF | hIL12A | hIL12B | hTSLP hIL18 | hIL18BP | hIL2/hIL2RA/hIL2RB/hIL2RG
And more...

download our catalog
An image of a C57BL/6 mouse.

Cytokine Receptors

These mouse models express humanized cytokines receptors. These models are suitable to assess the efficacy of drugs targeting cytokines receptors in fully immunocompetent mice.

Models available include:
hCCR2 | hCCR5 | hCCR8| hIFNGR1 | hIL2RG | hTNFRSF10B | hTNFR2/hFCGR2B
And more...

download our catalog
An image of a C57BL/6 mouse.

Metabolic Targets

These mouse models express humanized metabolic target genes. These models are suitable to assess the efficacy of drugs targeting metabolic pathway proteins in fully immunocompetent mice.

Models available include:
hPCSK9 | hAPOE4 | hALB | hGPL1R | hGIPR | hTTR
And more...

download our catalog
An image of a C57BL/6 mouse.

Viral Infection Receptors

Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. Humanized viral infection receptor knockin mouse models facilitate the study of host responses to viral infections.

Models available include:
hCD81 | hDPP4 | hOCLN | hACE2 | CAG-hACE2-IRES-Luc-Tg | hCD81/hOCLN
And more...

download our catalog

GET A QUOTE! 

Work with ingenious for your custom knockout mouse model.

Certainty

The model you design is the model we deliver.

Guaranteed Delivery

Assurance of your mouse model, not just your money back.

Value

Our proprietary technologies save time and money.

purchase
ingenious Targeting Laboratory Guarantee Badge

Order A Catalog Rodent Model

Please fill in the form below, and one of our scientific consultants will contact you within 1 business day. If you need consultation or assistance before submitting this form

Stay Ahead with Our Latest Insights

Join Our Community of Innovators