p53 Humanized Mouse Models
Customizable and regulatable p53 mutations, right at your fingertips.
ingenious targeting laboratory has developed over 100 humanized p53 mouse targeting vectors, or p53 humanized mouse models. Using the elegant p53 targeting system developed by ingenious, investigators studying the p53 gene and relevant protein pathways now have at their fingertips a suite of validated, cost effective products and services at their disposal. We offer a selection of pre- made vectors and targeted ES cell lines, using our own robust and validated ES cells, as well as P53 humanized mouse models. Genetically engineered mouse models of human disease, such as the p53, can provide new insights into cancer.
Vector Overview
- Mutations occur in the DNA binding domain of human exons 4-9 in the p53 gene
Benefits
Resources
1) The information regarding these targeting vectors, including the detailed design down to the base pairs, can be visualized online here.
2) p53 technology validation: Hanel W, Marchenko N, Xu S, Yu SX, Weng W, Moll U. 2013. Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. Cell Death Differ 20(7): 898-909.
