CRISPR Rat Models
Our process enables genome editing for consistent and precise targeting, achieving germline transmission modifications faster than traditional approaches.
Get your custom rat model in less time & with more certainty.
What Types of CRISPR Rat Models Are Possible?
The types of custom rat models that we can make for you are rat knockout models such as conventional knockout involving insertion of loxP sites. Rat knockins include point mutation knockin, reporter gene knockin, and humanized cDNA knockin.
| Conventional Knockout | Knockout/Reporter Knockin |
| Cre-conditional Knockout | Point Mutation Knockin |
| Reporter Gene Knockin | Humanized cDNA Knockin |
Rat Strains Available
Gene targeting in diverse rat strains, including:
Why Rat Models?
Rats have been used to model human disease for over a century within a broad range of science fields including neurobiology, cardiology, immunology and toxicology. Their size and physiological similarity to humans make them an ideal choice for many labs. For example, surgical manipulations can be performed on rats that are difficult or impossible with smaller rodents, and fewer animals are required to generate sufficient material for experiments. Previously it was difficult to genetically modify rats but these limitations have been overcome by the use of CRISPR technology.
