Tumor Targets

Humanized tumor target mice are immunocompetent mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigens, etc. These models can be used to evaluate the risk of on-target, off-tumor toxicities for targeted cancer drugs.

Immune Checkpoints

These mice express humanized immune checkpoint genes. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice. We offer:

Complement

These mouse models express humanized complement genes. These models are suitable to assess the efficacy of drugs targeting complement in fully immunocompetent mice.

Cytokines

Cytokines play key roles in host immune responses to infection, inflammation, trauma, sepsis, cancer, and reproduction. These mouse models express humanized cytokine genes. These models are suitable to assess the efficacy of drugs targeting cytokines in fully immunocompetent mice.

Cytokine Receptors

These mouse models express humanized cytokines receptors. These models are suitable to assess the efficacy of drugs targeting cytokines receptors in fully immunocompetent mice.

Metabolic Targets

These mouse models express humanized metabolic target genes. These models are suitable to assess the efficacy of drugs targeting metabolic pathway proteins in fully immunocompetent mice.

Viral Infection Receptors

Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. Humanized viral infection receptor knockin mouse models facilitate the study of host responses to viral infections.